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	henoch-sch?nlein purpura

Disease ID	1444
Disease	henoch-sch?nlein purpura
Definition	A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.
Synonym	acute vascular purpura allergic purpura allergic purpura (disorder) allergic purpura nos allergic purpura nos (disorder) anaphylactoid purpura autoimmune purpura autoimmune purpura (disorder) autoimmune purpura (disorder) [ambiguous] henoch purpura henoch schoenlein purpura henoch scholein purpura henoch schonlein henoch schonlein purpura henoch schonlein purpuras henoch schonlein syndrome henoch shonlein purpura henoch's purpura henoch-sch?nlein purpura (disorder) henoch-sch@nlein purpura henoch-schoenlein purpura henoch-schoenlein purpura (hsp) henoch-schoenlein vasculitis henoch-scholein purpura henoch-schonlein henoch-schonlein all. purpura henoch-schonlein purpura henoch-schonlein purpura (disorder) henoch-schonlein purpuras henoch-schÃ¶nlein purpura henoch-schÃ¶nlein purpura (disorder) hsp - henoch-schonlein purpura purpura allergic purpura, allergic purpura, anaphylactoid purpura, autoimmune purpura, henoch purpura, henoch schonlein purpura, henoch-schoenlein purpura, henoch-schonlein purpura, schoenlein henoch purpura, schoenlein-henoch purpura, schoenlein-henoch [disease/finding] purpura, schonlein henoch purpura, schonlein-henoch purpura: [allergic] or [henoch-schonlein allergy] purpura: [allergic] or [henoch-schonlein allergy] (disorder) purpuras, henoch schonlein purpuras, henoch-schonlein purpuras, schonlein-henoch schoenlein henoch purpura schoenlein-henoch purpura schonlein purpura, henoch schonlein purpuras, henoch schonlein-henoch purpura schonlein-henoch purpuras spring fever
Orphanet	ORPHANET:761
DOID	DOID:11123
ICD10	ICD10CM:D69.0
UMLS	C0034152
MeSH	D011695
SNOMED-CT	SNOMEDCT_US_2016_09_01:191306005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:65) C0042384 \| vasculitis \| 7 C0027697 \| nephritis \| 5 C0021933 \| intussusception \| 4 C0026934 \| mycoplasma \| 3 C0032285 \| pneumoniae \| 3 C0032302 \| mycoplasma pneumonia \| 3 C0085278 \| antiphospholipid syndrome \| 2 C0033687 \| proteinuria \| 2 C0151436 \| leukocytoclastic vasculitis \| 2 C0034150 \| purpura \| 2 C0003864 \| arthritis \| 2 C0040053 \| thrombosis \| 2 C0001339 \| acute pancreatitis \| 2 C0030305 \| pancreatitis \| 2 C0017658 \| glomerulonephritis \| 2 C0003873 \| rheumatoid arthritis \| 2 C0009324 \| ulcerative colitis \| 2 C0017178 \| gastrointestinal disorders \| 1 C0023890 \| liver cirrhosis \| 1 C0017178 \| gastrointestinal disorder \| 1 C0270612 \| leukoencephalopathy \| 1 C0271051 \| macular oedema \| 1 C0037199 \| sinusitis \| 1 C0041349 \| tubulointerstitial nephritis \| 1 C0003615 \| appendicitis \| 1 C0024440 \| cystoid macular oedema \| 1 C0014118 \| endocarditis \| 1 C0008325 \| cholecystitis \| 1 C0009319 \| colitis \| 1 C0031069 \| familial mediterranean fever \| 1 C0024110 \| lung abscess \| 1 C0013370 \| intestinal amebiasis \| 1 C0014534 \| epididymitis \| 1 C0042769 \| viral infection \| 1 C0038013 \| ankylosing spondylitis \| 1 C0242379 \| lung cancer \| 1 C0155773 \| portal vein thrombosis \| 1 C0042164 \| uveitis \| 1 C0020538 \| hypertension \| 1 C0018378 \| guillain-barre syndrome \| 1 C0021845 \| intestinal perforation \| 1 C0034152 \| henoch schonlein purpura \| 1 C0002438 \| amebiasis \| 1 C0456909 \| blindness \| 1 C0031154 \| peritonitis \| 1 C0155320 \| cortical blindness \| 1 C0027707 \| interstitial nephritis \| 1 C0007570 \| celiac disease \| 1 C0042769 \| virus infection \| 1 C0027726 \| nephrotic syndrome \| 1 C0033680 \| protein-losing enteropathy \| 1 C0026691 \| kawasaki disease \| 1 C0021831 \| enteropathy \| 1 C0149925 \| small cell lung cancer \| 1 C0267841 \| acalculous cholecystitis \| 1 C0001418 \| adenocarcinoma \| 1 C0019158 \| hepatitis \| 1 C0042165 \| anterior uveitis \| 1 C0022658 \| renal disease \| 1 C0152013 \| lung adenocarcinoma \| 1 C0015530 \| factor xiii deficiency \| 1 C0003460 \| anuria \| 1 C0442874 \| neuropathy \| 1 C0010072 \| coronary thrombosis \| 1 C0376545 \| hematological malignancies \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 718 \| C3 \| CTD_human 5328 \| PLAU \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:9) 3117 \| HLA-DQA1 \| CIPHER 4846 \| NOS3 \| CIPHER 7827 \| NPHS2 \| CIPHER 720 \| C4A \| CIPHER 7356 \| SCGB1A1 \| CIPHER 3123 \| HLA-DRB1 \| CIPHER 26191 \| PTPN22 \| CIPHER 718 \| C3 \| CTD_human 5328 \| PLAU \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:47) 56 \| ACRV1 \| 1.214 \| DISEASES 183 \| AGT \| 1.546 \| DISEASES 545 \| ATR \| 1.891 \| DISEASES 567 \| B2M \| 1.101 \| DISEASES 720 \| C4A \| 2.824 \| DISEASES 721 \| C4B \| 2.326 \| DISEASES 728 \| C5AR1 \| 1.575 \| DISEASES 959 \| CD40LG \| 3.999 \| DISEASES 1471 \| CST3 \| 1.559 \| DISEASES 1589 \| CYP21A2 \| 1.097 \| DISEASES 5169 \| ENPP3 \| 1.447 \| DISEASES 83715 \| ESPN \| 1.623 \| DISEASES 355 \| FAS \| 1.062 \| DISEASES 2204 \| FCAR \| 1.304 \| DISEASES 2224 \| FDPS \| 1.477 \| DISEASES 389549 \| FEZF1 \| 1.286 \| DISEASES 26762 \| HAVCR1 \| 1.286 \| DISEASES 3106 \| HLA-B \| 1.756 \| DISEASES 3123 \| HLA-DRB1 \| 2.616 \| DISEASES 3320 \| HSP90AA1 \| 4.447 \| DISEASES 3586 \| IL10 \| 1.442 \| DISEASES 3605 \| IL17A \| 2.248 \| DISEASES 29949 \| IL19 \| 1.949 \| DISEASES 3572 \| IL6ST \| 1.18 \| DISEASES 64423 \| INF2 \| 1.438 \| DISEASES 3920 \| LAMP2 \| 1.353 \| DISEASES 4153 \| MBL2 \| 1.308 \| DISEASES 4192 \| MDK \| 1.936 \| DISEASES 4318 \| MMP9 \| 1.222 \| DISEASES 114548 \| NLRP3 \| 1.077 \| DISEASES 5076 \| PAX2 \| 1.261 \| DISEASES 5277 \| PIGA \| 2.285 \| DISEASES 23556 \| PIGN \| 2.738 \| DISEASES 5420 \| PODXL \| 2.177 \| DISEASES 26191 \| PTPN22 \| 1.014 \| DISEASES 7732 \| RNF112 \| 1.134 \| DISEASES 6401 \| SELE \| 2.407 \| DISEASES 5265 \| SERPINA1 \| 1.534 \| DISEASES 169981 \| SPIN3 \| 3.259 \| DISEASES 129685 \| TAF8 \| 1.695 \| DISEASES 80222 \| TARS2 \| 1.844 \| DISEASES 123283 \| TARSL2 \| 1.88 \| DISEASES 7056 \| THBD \| 1.451 \| DISEASES 7099 \| TLR4 \| 1.665 \| DISEASES 7124 \| TNF \| 2.232 \| DISEASES 7133 \| TNFRSF1B \| 1.639 \| DISEASES 7148 \| TNXB \| 1.146 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1444
Disease	henoch-sch?nlein purpura
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:52) HP:0002633 \| Vasculitis \| 7 HP:0000123 \| Nephritis \| 5 HP:0002027 \| Abdominal pain \| 4 HP:0001369 \| Arthritis \| 3 HP:0012531 \| Pain \| 3 HP:0002576 \| Intussusception \| 3 HP:0002584 \| Intestinal hemorrhage \| 3 HP:0001298 \| Encephalopathy \| 3 HP:0000979 \| Purpura \| 2 HP:0100279 \| Ulcerative colitis \| 2 HP:0003613 \| Antiphospholipid antibodies \| 2 HP:0100584 \| Endocarditis \| 2 HP:0001733 \| Pancreatic inflammation \| 2 HP:0000093 \| Proteinuria \| 2 HP:0001945 \| Fever \| 2 HP:0001370 \| Rheumatoid arthritis \| 2 HP:0000099 \| Glomerular nephritis \| 2 HP:0001735 \| Acute pancreatitis \| 2 HP:0002586 \| Peritonitis \| 1 HP:0012122 \| Anterior uveitis \| 1 HP:0001970 \| Interstitial nephritis \| 1 HP:0001342 \| Intracerebral hemorrhage \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0005202 \| Helicobacter pylori infection \| 1 HP:0100519 \| Anuria \| 1 HP:0003326 \| Muscle pain \| 1 HP:0011128 \| Acute esophageal necrosis \| 1 HP:0000822 \| Hypertension \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0005318 \| Cerebral vasculitis \| 1 HP:0002664 \| Neoplasia \| 1 HP:0012596 \| Moderate proteinuria \| 1 HP:0000790 \| Hematuria \| 1 HP:0012735 \| Coughing \| 1 HP:0000100 \| Nephrosis \| 1 HP:0000246 \| Sinus inflammation \| 1 HP:0030357 \| Small cell lung carcinoma \| 1 HP:0000031 \| Epididymitis \| 1 HP:0100704 \| Cortical visual impairment \| 1 HP:0002242 \| Enteropathy \| 1 HP:0000554 \| Uveitis \| 1 HP:0030078 \| Lung adenocarcinoma \| 1 HP:0002243 \| Protein-losing enteropathy \| 1 HP:0000969 \| Dropsy \| 1 HP:0000618 \| Blindness \| 1 HP:0006689 \| Bacterial endocarditis \| 1 HP:0002583 \| Colitis \| 1 HP:0002608 \| Celiac disease \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1 HP:0002720 \| Decreased immunoglobulin A \| 1 HP:0030242 \| Blood clot in portal vein \| 1 HP:0011505 \| Cystoid macular edema \| 1

Disease ID	1444
Disease	henoch-sch?nlein purpura
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0019080 \| hemorrhage \| 3 C0009450 \| infection \| 2 C0030305 \| pancreatitis \| 2 C0021933 \| intussusception \| 2 C0020538 \| hypertension \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:4)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs28940579	22783597	4210	MEFV	umls:C0034152	BeFree	MEFV gene mutations (M694V, V726A, M680I, and A744S) in Iranian children with Henoch-Schönlein purpura.	0.009544073	2012	MEFV	16	3243310	A	T,G
rs28940580	22783597	4210	MEFV	umls:C0034152	BeFree	MEFV gene mutations (M694V, V726A, M680I, and A744S) in Iranian children with Henoch-Schönlein purpura.	0.009544073	2012	MEFV	16	3243447	C	T,G
rs3743930	20602240	4210	MEFV	umls:C0034152	BeFree	MEFV E148Q polymorphism is associated with Henoch-Schönlein purpura in Chinese children.	0.009544073	2010	MEFV	16	3254626	C	G
rs61732874	22783597	4210	MEFV	umls:C0034152	BeFree	MEFV gene mutations (M694V, V726A, M680I, and A744S) in Iranian children with Henoch-Schönlein purpura.	0.009544073	2012	MEFV	16	3243257	C	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1444
Disease	henoch-sch?nlein purpura
Case	(Waiting for update.)

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